Investigating the relationship between sleep disturbances and stroke recovery in Veterans
Official title: Sleep and Stroke
Funded at Harry S. Truman Memorial VA Hospital · NIH-11003659 · Data updated 2026-11-12
This study is looking at how sleep problems after a stroke can make it harder for Veterans to recover, and it aims to find ways to improve their sleep so they can heal better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harry S. Truman Memorial VA Hospital NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006240-02 |
| Project ID | NIH-11003659 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are middle-aged Veterans who have experienced an ischemic stroke and are suffering from sleep disturbances.
✕Less likely to help
Patients who have not experienced a stroke or do not have sleep disturbances may not benefit from this research.
What this research studies
This research focuses on understanding how sleep disturbances affect recovery in Veterans who have experienced ischemic strokes. It aims to develop animal models that replicate these sleep issues, which are common after a stroke and can hinder recovery. By studying the neuroanatomical factors involved, the research seeks to identify potential interventions that could improve sleep quality and, consequently, functional recovery in stroke patients. The findings could lead to new treatment strategies that target sleep disturbances as a modifiable factor in stroke rehabilitation.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery outcomes for stroke patients by addressing sleep disturbances.
How similar studies have gone: While the specific approach of using animal models to study sleep disturbances in stroke recovery is novel, there is existing research indicating that addressing sleep issues can improve recovery outcomes in stroke patients.
Where this research is happening
-
Harry S. Truman Memorial VA Hospital
Columbia, United States Active
Researchers
- Principal investigator: Thakkar, Mahesh M — Harry S. Truman Memorial VA Hospital
- Study coordinator: Thakkar, Mahesh M
Related research
Other NIH-funded projects on the same topics.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.