Investigating the relationship between joint movement and tissue changes in knee osteoarthritis
Simultaneous Imaging of Tissue Biochemistry and Metabolism associated with Biomechanics in Patella Femoral Joint Osteoarthritis
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11037932
This study is looking at how the way your joints move can influence the progression of knee osteoarthritis, and it's for people with this condition who want to help researchers learn more about it over two years using special imaging techniques.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11037932 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how biomechanics, specifically joint movement, affects the progression of patellofemoral joint osteoarthritis (PFJOA). Using advanced imaging techniques like Proton Emission Tomography and Magnetic Resonance Imaging (PET-MRI), the study aims to capture detailed information about cartilage and bone interactions in patients with PFJOA. Participants will undergo assessments at the beginning of the study and again after two years to track changes over time. The goal is to identify specific patterns that could help in understanding and potentially treating this common condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with isolated patellofemoral joint osteoarthritis.
Not a fit: Patients with knee osteoarthritis not limited to the patellofemoral joint or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment strategies for patients suffering from knee osteoarthritis.
How similar studies have performed: Other research has shown promising results using advanced imaging techniques to study joint diseases, indicating that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SOUZA, RICHARD BRIAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SOUZA, RICHARD BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.