Investigating the relationship between a protein and HIV transcription
Transcriptional Crosstalk between DUX4-FL and HIV
This study is looking at how a specific protein called DUX4-FL interacts with HIV in certain immune cells, with the goal of finding new ways to stop the virus from becoming active again in people living with HIV who are on treatment.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10693294 on NIH RePORTER |
What this research studies
This research explores how the full-length isoform of the double homeobox protein 4 (DUX4-FL) interacts with HIV in memory CD4+ T cells. It aims to understand the mechanisms behind HIV transcription and how inhibitors can be used to block this process, potentially leading to a functional cure for HIV. By examining the role of DUX4-FL in promoting HIV transcription, the study seeks to identify new antiviral targets and strategies to reduce residual HIV in patients undergoing antiretroviral therapy. The approach involves using various inhibitors to disrupt the transcription process and prevent viral rebound.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and have residual HIV transcription.
Not a fit: Patients who are not living with HIV or those who have not been treated with antiretroviral therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce HIV levels in patients and potentially achieve a functional cure.
How similar studies have performed: Other research has shown promise in targeting HIV transcription and utilizing inhibitors, suggesting that this approach could be effective.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Mediouni Jablonski, Sonia — University of Florida
- Study coordinator: Mediouni Jablonski, Sonia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.