Investigating the receptor for the hormone asprosin and its role in appetite regulation
The CNS Receptor For Asprosin
This study is looking at how a hormone called asprosin affects hunger and weight by interacting with certain brain receptors, and it could help find new ways to treat obesity and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10897270 on NIH RePORTER |
What this research studies
This research focuses on understanding how asprosin, a hormone that increases appetite and glucose production, interacts with specific receptors in the brain. By identifying the cell-surface receptor for asprosin, the study aims to explore its effects on appetite stimulation and body weight regulation. The research involves advanced techniques like mass spectrometry to analyze brain tissue and determine how asprosin influences neuronal activity. Patients may benefit from insights that could lead to new treatments for obesity and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals struggling with obesity or metabolic disorders related to appetite regulation.
Not a fit: Patients who are underweight or have conditions that cause low appetite may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for obesity by targeting the mechanisms of appetite regulation.
How similar studies have performed: Other research has shown promising results with similar approaches targeting appetite regulation and metabolic disorders, indicating potential for success in this area.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Chopra, Atul — Case Western Reserve University
- Study coordinator: Chopra, Atul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.