Investigating the properties of eye-supporting fibers affected by genetic mutations
Structural, mechanical, and cell biological properties of the ciliary zonule
This study is looking at how changes in certain proteins that support the eye's lens can cause problems like cataracts and lens dislocation, using mice to help understand these issues better and find ways to prevent or treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11030300 on NIH RePORTER |
What this research studies
This research focuses on the ciliary zonule, a structure that supports the eye's lens and is crucial for its function. It aims to understand how genetic mutations in zonular proteins lead to various eye conditions, such as cataracts and lens dislocation. By modeling specific syndromes in mice, the researchers will use advanced imaging and material testing techniques to analyze how these mutations affect the zonule's structure and mechanical properties. The study also explores the role of intraocular pressure in the development of the zonule, which could provide insights into preventing or treating related eye disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations linked to syndromic and non-syndromic eye conditions, such as Marfan Syndrome or ectopia lentis.
Not a fit: Patients without genetic predispositions to eye disorders or those with unrelated ocular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with genetic eye disorders.
How similar studies have performed: Previous research has shown success in understanding the structural properties of eye-related tissues, making this approach promising yet still innovative.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Bassnett, Steven — Washington University
- Study coordinator: Bassnett, Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.