Investigating the properties of biomolecular condensates in neurodegenerative diseases
Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy
This study is looking at tiny structures in our cells that are important for keeping them healthy, especially in conditions like ALS and frontotemporal dementia, to help find new ways to treat these diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10877723 on NIH RePORTER |
What this research studies
This research focuses on understanding the physical properties of ribonucleoprotein (RNP) granules, which are crucial for cellular function and are implicated in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). By developing advanced microscopy techniques, the researchers aim to explore how these granules transition between different states, which can affect cell health. Patients may benefit from insights gained about the mechanisms behind these diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
Not a fit: Patients with other neurological disorders not related to ALS or FTD may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating neurodegenerative diseases such as ALS and FTD.
How similar studies have performed: While the approach is innovative, similar research has shown promise in understanding cellular processes related to neurodegeneration.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Banerjee, Priya R. — State University of New York at Buffalo
- Study coordinator: Banerjee, Priya R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.