Investigating the progression of cardiovascular disease in diverse populations
Official title: EOI::DEFEND THE SPEND::EOI NOTICE OF TERMINATION FOR CONVENIENCE
Funded at Columbia University Health Sciences · NIH-11310375 · Data updated 2026-11-12
This study is looking at how heart disease can develop in people aged 45-84 who don’t have any obvious signs of it yet, using advanced imaging and health checks over about 20 years to help us understand what might lead to heart problems later on.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 19, 2024 |
| Project end | April 11, 2025 |
| Funding year | 2025 |
| Award (this year) | $247,574 |
| NIH project number | 75N92020D00002-0-759202500001-1 |
| Project ID | NIH-11310375 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men and women aged 45-84 with no prior evidence of clinical cardiovascular disease.
✕Less likely to help
Patients who are younger than 45 or those who already have clinical cardiovascular disease may not benefit from this research.
What this research studies
This research focuses on understanding the predictors and progression of subclinical cardiovascular disease (CVD) in a diverse group of men and women aged 45-84 who initially showed no signs of clinical CVD. Participants will undergo various imaging techniques, including computed tomography and cardiac MRI, alongside assessments of genetic variants and other health indicators. The study aims to enhance the understanding of how subclinical conditions develop into clinical diseases over time, with follow-ups spanning approximately 20 years. By analyzing data from a large cohort, the research seeks to identify key factors that contribute to cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and prevention of cardiovascular diseases.
How similar studies have gone: Previous studies have shown success in understanding cardiovascular disease progression using similar methodologies, indicating a strong foundation for this research.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Shea, Steven J — Columbia University Health Sciences
- Study coordinator: Shea, Steven J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.