Investigating the orexin system for treating PTSD and related psychosis
The orexin system as a target for PTSD and comorbid psychosis
['FUNDING_OTHER'] · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · NIH-10926781
This study is looking at how a brain system related to sleep and wakefulness might affect people with PTSD who also have psychotic symptoms, and it’s testing a safe medication to see if it can help improve their symptoms in a new way.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTH TEXAS VETERANS HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10926781 on ClinicalTrials.gov |
What this research studies
This research explores the role of the orexin system in patients with PTSD who also experience psychotic symptoms. It aims to understand how specific brain circuits, particularly involving the insular cortex, influence dopamine function and behavior in these patients. By using an FDA-approved drug called Suvorexant, which targets orexin receptors, the study seeks to identify new therapeutic strategies that could alleviate symptoms without the adverse effects associated with traditional treatments. The research will involve animal models to provide insights that could eventually translate to human applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with PTSD who also experience psychotic symptoms.
Not a fit: Patients without PTSD or those who do not experience psychotic symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatments for patients suffering from PTSD and comorbid psychosis.
How similar studies have performed: Previous studies have shown promise in using orexin receptor antagonists for treating stress-related conditions, suggesting potential for success in this novel approach.
Where this research is happening
SAN ANTONIO, UNITED STATES
- SOUTH TEXAS VETERANS HEALTH CARE SYSTEM — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LODGE, DANIEL — SOUTH TEXAS VETERANS HEALTH CARE SYSTEM
- Study coordinator: LODGE, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.