Investigating the NOTCH4 pathway's role in asthma severity among urban school children.
Novel NOTCH4 Pathway of Asthma Severity in Urban School Children: Clinical Research Center, Boston Children’s Hospital
This study is looking at how a specific pathway in our genes might affect how severe asthma is for kids living in cities, and it’s for children who visit allergy and asthma clinics at Boston Children's Hospital.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11034140 on NIH RePORTER |
What this research studies
This research focuses on understanding how the NOTCH4 pathway influences asthma severity in children living in urban environments. The team at Boston Children's Hospital will recruit participants from local allergy and asthma clinics, utilizing advanced clinical and laboratory techniques to analyze genetic and environmental factors affecting asthma. By examining these interactions, the study aims to identify potential biomarkers and therapeutic targets for asthma management. Participants will undergo clinical assessments and provide biological samples to support the research.
Who could benefit from this research
Good fit: Ideal candidates for this research are urban school children diagnosed with asthma or related allergic diseases.
Not a fit: Patients without asthma or those living outside urban environments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved asthma treatments tailored to the specific needs of urban children.
How similar studies have performed: Previous research has shown promise in understanding asthma mechanisms through genetic and environmental studies, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Phipatanakul, Wanda — Boston Children's Hospital
- Study coordinator: Phipatanakul, Wanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.