Investigating the molecular mechanisms of type 2 diabetes using human pancreas analysis
Human Pancreas Analysis Program-T2D
This study is looking at how the pancreas changes in people with type 2 diabetes, including those who are at risk or receiving different treatments, to better understand what causes problems with insulin production.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10795651 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular changes that occur in the pancreas of individuals with type 2 diabetes (T2D). By analyzing pancreatic tissue and islets from donors with varying stages of diabetes, including prediabetes and those treated with different therapies, the team aims to uncover the genetic and molecular factors that contribute to islet dysfunction. The study employs advanced experimental techniques to comprehensively phenotype pancreatic islets and analyze tissue architecture, providing insights into the underlying mechanisms of T2D.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with prediabetes or type 2 diabetes, as well as healthy controls.
Not a fit: Patients with type 1 diabetes or other forms of diabetes unrelated to insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with type 2 diabetes.
How similar studies have performed: Previous research has shown promise in understanding diabetes through similar analyses of pancreatic tissue, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Powers, Alvin C — Vanderbilt University Medical Center
- Study coordinator: Powers, Alvin C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.