Investigating the molecular causes of alcohol use disorder
Official title: Molecular Dissection of Alcohol Use Disorder Through Targeted Brain Multi-omics
Funded at Yale University · NIH-10879232 · Data updated 2026-11-12
This study is looking at how alcohol use disorder affects the brain by comparing brain samples from people with this condition to those with depression and those without any disorders, to help find better ways to diagnose and treat alcohol addiction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $594,784 |
| NIH project number | 1R01AA031017-01A1 |
| Project ID | NIH-10879232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with alcohol use disorder, as well as individuals with major depressive disorder and neurotypical controls for comparison.
✕Less likely to help
Patients who do not have alcohol use disorder or related psychiatric conditions may not benefit from this research.
What this research studies
This research aims to understand the molecular mechanisms behind alcohol use disorder (AUD) by examining brain tissues from individuals with AUD and comparing them to those with major depressive disorder and neurotypical controls. The study will analyze gene expression and DNA methylation in various brain regions to identify changes associated with alcohol addiction. By uncovering these molecular differences, the research seeks to develop better diagnostic tools and personalized treatment options for those affected by AUD.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and targeted therapies for individuals struggling with alcohol use disorder.
How similar studies have gone: Previous research has shown promise in understanding neuropsychiatric disorders through multi-omic approaches, indicating potential for success in this area.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Girgenti, Matthew J — Yale University
- Study coordinator: Girgenti, Matthew J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.