Investigating the mechanisms of central sleep apnea to improve treatment options
Official title: Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment
Funded at John D Dingell VA Medical Center · NIH-11051104 · Data updated 2026-11-12
This study is looking at how to improve treatments for central sleep apnea, especially for people with heart failure or those using opioids, by testing different combinations of breathing devices and medications to help normalize breathing patterns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | January 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01CX001944-06 |
| Project ID | NIH-11051104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with central sleep apnea, particularly those with heart failure or those who are opioid users.
✕Less likely to help
Patients with other forms of sleep apnea or those without the specific conditions being studied may not benefit from this research.
What this research studies
This research focuses on understanding the physiological mechanisms behind central sleep apnea (CSA) to develop better treatment strategies. It aims to explore combination therapies that include positive airway pressure (PAP) and pharmacological agents to normalize breathing patterns. The study will specifically look at how different therapies can target various aspects of the respiratory feedback loop, particularly in patients with heart failure or those using opioids. By conducting these experiments, the research seeks to provide insights that could lead to more effective interventions for CSA.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from central sleep apnea, potentially enhancing their quality of life.
How similar studies have gone: Previous research has shown promise in using combination therapies for sleep apnea, indicating that this approach may yield beneficial results.
Where this research is happening
-
John D Dingell VA Medical Center
Detroit, United States Active
Researchers
- Principal investigator: Badr, M.safwan — John D Dingell VA Medical Center
- Study coordinator: Badr, M.safwan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.