Investigating the mechanisms of central sleep apnea to improve treatment options
Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment
This study is looking at how to improve treatments for central sleep apnea, especially for people with heart failure or those using opioids, by testing different combinations of breathing devices and medications to help normalize breathing patterns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | John D Dingell VA Medical Center NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11051104 on NIH RePORTER |
What this research studies
This research focuses on understanding the physiological mechanisms behind central sleep apnea (CSA) to develop better treatment strategies. It aims to explore combination therapies that include positive airway pressure (PAP) and pharmacological agents to normalize breathing patterns. The study will specifically look at how different therapies can target various aspects of the respiratory feedback loop, particularly in patients with heart failure or those using opioids. By conducting these experiments, the research seeks to provide insights that could lead to more effective interventions for CSA.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with central sleep apnea, particularly those with heart failure or those who are opioid users.
Not a fit: Patients with other forms of sleep apnea or those without the specific conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients suffering from central sleep apnea, potentially enhancing their quality of life.
How similar studies have performed: Previous research has shown promise in using combination therapies for sleep apnea, indicating that this approach may yield beneficial results.
Where this research is happening
Detroit, United States
- John D Dingell VA Medical Center — Detroit, United States (Active)
Researchers
- Principal investigator: Badr, M.safwan — John D Dingell VA Medical Center
- Study coordinator: Badr, M.safwan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.