Investigating the mechanisms behind Alzheimer's disease in veterans
Official title: A Multifactorial Mechanism for Alzheimer's Disease
Funded at VA Western New York Healthcare System · NIH-10923244 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects the brain, especially in veterans, by examining brain tissue after death to find out which genes and proteins are different in people with the disease, with the hope of discovering new ways to help improve memory and thinking skills.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Western New York Healthcare System NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | October 1, 2024 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006357-01A1 |
| Project ID | NIH-10923244 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans experiencing cognitive impairment or at risk for Alzheimer's disease.
✕Less likely to help
Patients who do not have a history of cognitive impairment or Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the biological mechanisms that contribute to cognitive decline in Alzheimer's disease, particularly among veterans. By analyzing postmortem brain tissue, the study aims to identify specific genes and proteins that are altered in Alzheimer's patients. The researchers will use advanced techniques to explore how these changes affect brain function and contribute to dementia. This multifaceted approach seeks to uncover potential targets for new treatments that could improve cognitive health in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous research has shown promise in identifying molecular targets for Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
-
VA Western New York Healthcare System
Buffalo, United States Active
Researchers
- Principal investigator: Yan, Zhen — VA Western New York Healthcare System
- Study coordinator: Yan, Zhen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.