Investigating the MAS1 receptor's role in neuropsychiatric conditions
Official title: In Vivo Probes of Mas1 Receptor
Funded at Research Triangle Institute · NIH-11010785 · Data updated 2026-11-12
This study is looking for new ways to help people with PTSD and other mental health issues by testing small molecules that can activate a specific brain receptor, which might improve our understanding of how anxiety and stress work in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Triangle Institute NIH-funded |
| Lab location | 1 site (Research Triangle Park, United States) |
| Project start | January 12, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $545,223 |
| NIH project number | 5R01MH135136-02 |
| Project ID | NIH-11010785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with PTSD or other anxiety-related disorders.
✕Less likely to help
Patients with conditions unrelated to neuropsychiatric disorders may not benefit from this research.
What this research studies
This research focuses on developing small molecule agonists for the MAS1 receptor to explore its involvement in neuropsychiatric disorders like PTSD. By creating high-quality probes, the study aims to enhance our understanding of how this receptor functions in the brain and its potential effects on anxiety and stress responses. The research employs advanced screening techniques to identify promising compounds and optimize their properties for better brain exposure. This could lead to new therapeutic options for patients suffering from mental health conditions.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neuropsychiatric conditions, improving the quality of life for affected patients.
How similar studies have gone: Previous research has shown promise in targeting similar receptors for mental health treatments, indicating potential for success in this approach.
Where this research is happening
-
Research Triangle Institute
Research Triangle Park, United States Active
Researchers
- Principal investigator: Maitra, Rangan — Research Triangle Institute
- Study coordinator: Maitra, Rangan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.