Investigating the loss of pancreatic function in children at risk for type 1 diabetes
Understanding pancreatic endocrine and exocrine loss in pre-type 1 diabetes
This study is looking at how the pancreas changes in children who have a family member with type 1 diabetes, to help us understand what might lead to the disease and find ways to predict it earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10915393 on NIH RePORTER |
What this research studies
This research focuses on understanding the early physiological changes that occur in the pancreas of children who are at risk for developing type 1 diabetes, particularly those with a first-degree relative diagnosed with the condition. By examining biomarkers and pancreatic size, the study aims to identify factors that contribute to the autoimmune destruction of insulin-producing cells. Participants may undergo assessments involving blood tests and imaging to track changes in pancreatic function over time. The goal is to fill gaps in knowledge about how type 1 diabetes progresses and to identify new biomarkers that could help predict the onset of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have a first-degree relative with type 1 diabetes.
Not a fit: Patients who do not have a family history of type 1 diabetes or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management strategies for children at risk of developing type 1 diabetes.
How similar studies have performed: Previous studies have shown promise in identifying biomarkers for type 1 diabetes progression, but this specific approach is novel and aims to deepen understanding of pancreatic changes.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Campbell-Thompson, Martha — University of Florida
- Study coordinator: Campbell-Thompson, Martha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.