Investigating the long-term effects of traumatic brain injury on neurodegeneration.
Clinical & biological signatures of post-traumatic neurodegeneration: Leveraging the TBI Model Systems of Care to accelerate in vivo diagnosis of the late effects of TBI (LETBI)
This study is looking at how long-term effects of traumatic brain injury (TBI) differ from conditions like Alzheimer's disease in people who had a TBI at least five years ago, and it will involve regular check-ups every few years to track their brain health and help improve future care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10524430 on NIH RePORTER |
What this research studies
This research focuses on understanding the clinical and biological features that differentiate chronic effects of traumatic brain injury (TBI) from progressive neurodegeneration. It involves a longitudinal study of TBI survivors who are at least five years post-injury, utilizing multimodal data collection methods to assess their cognitive and neurological health over time. Participants will undergo follow-up visits every 2-3 years to monitor changes and identify potential risks for conditions like Alzheimer's disease. The study aims to leverage existing data from TBI Model Systems to enhance diagnosis and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of moderate to severe traumatic brain injury who are at least five years post-injury.
Not a fit: Patients who have not experienced traumatic brain injury or those with mild injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatment options for individuals suffering from the long-term effects of traumatic brain injury.
How similar studies have performed: Previous research has shown promise in understanding the long-term effects of TBI, but this specific approach is novel in its comprehensive longitudinal analysis.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dams-O'connor, Kristen — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dams-O'connor, Kristen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.