Investigating the long-term effects of sepsis on the immune system.
Official title: BLRD Research Career Scientist Award Application
Funded at Minneapolis VA Medical Center · NIH-10950294 · Data updated 2026-11-12
This study is looking at how sepsis impacts the immune system in people who survive it, especially why some of them continue to feel weak and get sick more often, with the hope of finding ways to help them recover better and live healthier lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Minneapolis VA Medical Center NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5IK6BX006192-03 |
| Project ID | NIH-10950294 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have survived sepsis and are experiencing ongoing health issues related to their condition.
✕Less likely to help
Patients who have not experienced sepsis or those with unrelated chronic health conditions may not benefit from this research.
What this research studies
This research focuses on understanding how sepsis affects the immune system in patients, particularly those who survive the condition. It aims to explore the persistent immune suppression that many sepsis survivors experience, which can lead to recurrent infections and poor long-term health outcomes. The research employs a combination of preclinical models and human samples to investigate these effects, with the goal of identifying potential interventions to improve recovery and quality of life for patients. By studying these mechanisms, the research seeks to enhance the management of sepsis and its aftermath.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and recovery strategies for sepsis survivors, enhancing their long-term health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding sepsis-induced immune suppression, indicating that this area of study has potential for significant advancements.
Where this research is happening
-
Minneapolis VA Medical Center
Minneapolis, United States Active
Researchers
- Principal investigator: Griffith, Thomas S — Minneapolis VA Medical Center
- Study coordinator: Griffith, Thomas S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.