Investigating the long-term effects of preeclampsia on offspring through B cells
Official title: B Cells in Preeclampsia: Long-term Effects on Offspring
Funded at University of Mississippi Med Ctr · NIH-11162701 · Data updated 2026-11-12
This study is looking at how preeclampsia during pregnancy can impact the immune system and long-term health of both mothers and their children, and it’s testing a new treatment that might help prevent some of these health issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | April 11, 2025 |
| Project end | April 10, 2028 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32HD118681-01 |
| Project ID | NIH-11162701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include pregnant women diagnosed with preeclampsia and their offspring, particularly those at risk for long-term health complications.
✕Less likely to help
Patients who have not experienced preeclampsia or do not have a family history of related health issues may not benefit from this research.
What this research studies
This research focuses on understanding how preeclampsia, a pregnancy complication characterized by high blood pressure and organ dysfunction, affects the immune system and long-term health of offspring. The study examines the role of activated B cells and their production of specific autoantibodies that may contribute to health issues in both mothers and their children. By exploring a novel peptide treatment that has shown promise in preclinical models, the research aims to identify potential preventive strategies for the adverse effects associated with preeclampsia. Patients may be involved in the study to help assess the implications of these findings on future health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for health issues in children born to mothers who experienced preeclampsia.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms involved in preeclampsia, but this specific approach using the novel peptide is relatively novel.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Campbell, Nathan E. — University of Mississippi Med Ctr
- Study coordinator: Campbell, Nathan E.
Related research
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This study explores how a protein called folate receptor beta on placental immune cells may drive or worsen preeclampsia in pregnancy, with hopes of finding new ways to prevent or treat the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.