Investigating the long-term effects of COVID-19 on mothers and their babies

COVID-19 Mother Baby Outcomes (COMBO): brain-behavior functioning

NIH-funded research Columbia University Health Sciences · NIH-11073000

This study is looking at how getting COVID-19 during pregnancy might affect babies' brain development and behavior, and it’s for moms and their little ones born during the pandemic, as researchers compare those who were exposed to the virus with those who weren't to see how they grow and develop over time.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-11073000 on NIH RePORTER

What this research studies

This research examines the potential long-term impacts of maternal COVID-19 infection during pregnancy on the brain and behavior of infants born during the pandemic. It focuses on a group of mother-child pairs, comparing those exposed to the virus with those who were not, to assess socioemotional development and caregiving behaviors. The study will track these dyads from before birth until the children are 18 months old, using various assessments to understand any changes in their health and development.

Who could benefit from this research

Good fit: Ideal candidates for this research include mothers who were infected with COVID-19 during pregnancy and their newborns.

Not a fit: Patients who were not pregnant during the COVID-19 pandemic or whose mothers did not contract the virus may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide insights into the effects of maternal COVID-19 infection on child development, potentially guiding future healthcare practices.

How similar studies have performed: Other research has indicated that prenatal infections can have lasting effects on child development, suggesting that this approach may yield valuable insights.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Affective Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.