Investigating the long-term effects of COVID-19 on individuals with Alzheimer's disease and related dementias.
Official title: Post-Acute Sequelae of SARS-CoV-2 Infection and Subsequent Disease Progression in Individuals with AD/ADRD: Influence of the Social and Environmental Determinants of Health
Funded at Brigham and Women's Hospital · NIH-10751275 · Data updated 2026-11-12
This study is looking at how COVID-19 might affect people with Alzheimer's and similar memory issues, to see if getting the virus makes their thinking and memory problems worse, while also considering how their surroundings and social situations play a role.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,561,480 |
| NIH project number | 1RF1AG084178-01 |
| Project ID | NIH-10751275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who have also had a COVID-19 infection.
✕Less likely to help
Patients who have not been diagnosed with cognitive impairments or have not contracted COVID-19 may not benefit from this research.
What this research studies
This research focuses on understanding how COVID-19 affects individuals with cognitive impairments, particularly those with Alzheimer's disease and related dementias. It aims to explore the post-acute sequelae of SARS-CoV-2 infection, which may lead to worsening cognitive and memory disorders. By utilizing electronic health records, the study will analyze longitudinal data to identify the impact of COVID-19 on disease progression in these vulnerable populations. The research will also consider social and environmental factors that may influence health outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive decline in patients recovering from COVID-19.
How similar studies have gone: Previous research has indicated that COVID-19 can lead to neurological complications, but this specific focus on cognitively impaired individuals is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Hu, Hui — Brigham and Women's Hospital
- Study coordinator: Hu, Hui
Related research
Other NIH-funded projects on the same topics.
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How COVID-19 infection and genes may influence memory and dementia risk
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This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.
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How COVID-19 and genetics influence memory and dementia risk in older adults
This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.
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This project in Kenya checks how having had COVID-19 might influence the reactivation of latent tuberculosis in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.