Investigating the long-term effects of congenital cytomegalovirus infection in infants
Official title: Clinically Recognized Congenital Cytomegalovirus Infection and Risk of Long-Term Neurologic and Non-neurologic Complications: Evidence from a Nationwide Cohort
Funded at Brigham and Women's Hospital · NIH-11015053 · Data updated 2026-11-12
This study is looking at how congenital cytomegalovirus (cCMV) infection can affect babies in the long run, so we can better understand the challenges they might face and find ways to help them and their families.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 24, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $86,815 |
| NIH project number | 5R03AI178363-02 |
| Project ID | NIH-11015053 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants diagnosed with congenital cytomegalovirus infection, particularly those showing symptoms at birth.
✕Less likely to help
Patients who do not have congenital cytomegalovirus infection or those who are older than 11 years may not benefit from this research.
What this research studies
This research focuses on congenital cytomegalovirus (cCMV) infection, which is the most common congenital infection in the US, affecting one in every 200 infants. The study aims to gather high-quality evidence on the long-term neurologic and non-neurologic complications that may arise from cCMV infection in newborns. By analyzing a nationwide cohort, the research will assess the risks associated with cCMV and evaluate the effectiveness of available treatments. This could help improve understanding and management of the condition for affected infants and their families.
Why it matters
Potential benefit: If successful, this research could lead to better identification and treatment strategies for infants affected by congenital cytomegalovirus infection, potentially reducing long-term complications.
How similar studies have gone: Previous studies have shown some success in understanding the effects of congenital infections, but this specific investigation into cCMV's long-term outcomes is relatively novel.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Zhu, Yanmin — Brigham and Women's Hospital
- Study coordinator: Zhu, Yanmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.