Investigating the long-term effects of azithromycin on childhood obesity and neurodevelopment after cesarean delivery
Childhood follow-up study of obesity and neurodevelopment after perinatal exposure to adjunctive azithromycin prophylaxis for cesarean delivery
This study is looking at how giving the antibiotic azithromycin to mothers during childbirth affects their children's growth and brain development, especially for those born by cesarean section, and it compares these kids to others who didn't get the antibiotic to see if there are any long-term effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11070334 on NIH RePORTER |
What this research studies
This research examines how exposure to azithromycin during the perinatal period affects childhood obesity and neurodevelopment in children born via cesarean delivery. It compares outcomes in children who were exposed to azithromycin with those who received a placebo, focusing on growth patterns and cognitive development. The study involves a large cohort of children and aims to provide insights into the long-term implications of antibiotic use during delivery. By following up with these children over several years, the research seeks to understand any potential adverse effects linked to azithromycin exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0 to 11 years who were born via cesarean delivery and were exposed to azithromycin or placebo during the perinatal period.
Not a fit: Patients who were not born via cesarean delivery or did not receive azithromycin during the perinatal period are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved guidelines for antibiotic use during cesarean deliveries, ultimately enhancing child health outcomes.
How similar studies have performed: Previous studies have shown significant benefits from azithromycin in reducing maternal infections, but this research is novel in its focus on long-term childhood outcomes.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Subramaniam, Akila — University of Alabama at Birmingham
- Study coordinator: Subramaniam, Akila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.