Investigating the links between blood cell mutations, cognitive decline, and kidney function in older adults
Clonal hematopoiesis, mild cognitive impairment and kidney function decline
This study is looking at how changes in certain blood cells might be linked to memory problems and kidney issues in older adults, and it aims to find out more about how these health challenges are connected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11078186 on NIH RePORTER |
What this research studies
This research explores how clonal hematopoiesis, a condition where certain blood cells mutate and grow uncontrollably, may contribute to cognitive decline and kidney function deterioration in older adults. The study aims to identify the relationship between these blood mutations and conditions like mild cognitive impairment and dementia, as well as chronic kidney disease. By examining the role of the bone marrow fat environment and blood metabolites, researchers hope to uncover new insights into the underlying mechanisms of these age-related health issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing mild cognitive impairment or those at risk for cognitive decline and kidney function issues.
Not a fit: Patients who are younger than 21 years old or do not have any cognitive or kidney function impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline and kidney disease in older adults.
How similar studies have performed: While there is existing research on the links between cognitive decline and kidney function, the specific investigation of clonal hematopoiesis in this context is relatively novel.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Chonchol, Michel Benjamin — University of Colorado Denver
- Study coordinator: Chonchol, Michel Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.