Investigating the link between weight, inflammation, and Alzheimer's disease in individuals with Down syndrome
Weight, inflammation, and Alzheimer's disease in Down syndrome
This study is looking at how body weight and inflammation might affect the risk of developing Alzheimer's disease in adults with Down syndrome, and it hopes to find ways to help prevent this condition by analyzing data over three years.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11059596 on NIH RePORTER |
What this research studies
This research focuses on understanding how body weight and inflammation may influence the development of Alzheimer's disease in adults with Down syndrome. It aims to analyze existing data to evaluate the relationship between body mass index (BMI), weight changes, and Alzheimer's disease biomarkers over a period of 36 months. By examining cognitive performance and the timing of Alzheimer's symptoms, the study seeks to identify potential preventative measures for this high-risk population. Participants will contribute to a better understanding of how lifestyle factors may impact Alzheimer's disease progression in individuals with Down syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older with Down syndrome who are at risk for developing Alzheimer's disease.
Not a fit: Patients without Down syndrome or those who are not at risk for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that help delay or prevent Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has indicated a correlation between obesity and Alzheimer's disease risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Fleming, Victoria — University of Wisconsin-Madison
- Study coordinator: Fleming, Victoria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.