Investigating the link between viral infections and type 1 diabetes in children
Official title: Virome and Immune Responses associated with IA and Type 1 Diabetes
Funded at Baylor College of Medicine · NIH-11047728 · Data updated 2026-11-12
This study is looking at how long-lasting infections with a certain virus might play a role in causing type 1 diabetes in kids, and it involves testing samples from children who were part of a previous study to better understand how these infections affect their immune systems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | March 5, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,216,506 |
| NIH project number | 5R01DK138372-02 |
| Project ID | NIH-11047728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-15 years who may be at risk for type 1 diabetes due to prolonged viral infections.
✕Less likely to help
Patients who are older than 15 years or do not have a history of viral infections related to type 1 diabetes may not benefit from this research.
What this research studies
This research aims to explore how prolonged infections with Type B enteroviruses may contribute to the development of islet autoimmunity and type 1 diabetes in children. By analyzing samples such as white blood cells, nasal swabs, and plasma from 450 children previously enrolled in the TEDDY study, the researchers will assess immune responses and viral presence. The study will utilize advanced techniques like qRT-PCR and multi-‘omic single cell analysis to uncover the mechanisms behind these infections and their potential role in triggering autoimmune responses. This comprehensive approach seeks to provide insights that could lead to better understanding and prevention of type 1 diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing type 1 diabetes in children by identifying viral triggers.
How similar studies have gone: Previous research has indicated a strong link between viral infections and autoimmune conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Lloyd, Richard E — Baylor College of Medicine
- Study coordinator: Lloyd, Richard E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.