Investigating the link between uric acid, klotho, and salt sensitivity in young adults born preterm
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
This study is looking at how high blood pressure and heart problems can develop in young adults who were born early, by checking if higher levels of uric acid and how their bodies react to salt are linked to these issues, with the hope of finding better ways to prevent and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10669055 on NIH RePORTER |
What this research studies
This research focuses on understanding how hypertension and cardiovascular diseases develop in young adults who were born prematurely. It aims to explore the relationship between uric acid levels, a substance that may be elevated in these individuals, and salt sensitivity of blood pressure, which can contribute to hypertension. By studying these factors, the research seeks to uncover the underlying mechanisms that lead to increased cardiovascular risk in this population. The findings could help in developing targeted prevention and treatment strategies for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research are young adults aged 12 to 20 who were born prematurely and may be experiencing hypertension or cardiovascular issues.
Not a fit: Patients who were not born preterm or who do not have hypertension or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for hypertension and cardiovascular disease in young adults born preterm.
How similar studies have performed: While the specific investigation of uric acid and klotho in relation to salt sensitivity in preterm individuals is novel, related studies have shown that understanding these factors can lead to significant advancements in managing hypertension.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Chappell, Mark C — Wake Forest University Health Sciences
- Study coordinator: Chappell, Mark C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.