Investigating the link between traumatic brain injury and Alzheimer's disease risk
Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
This study is looking at how having a traumatic brain injury or repeated head impacts might affect the chances of developing Alzheimer's disease and other types of dementia, and it's for anyone interested in understanding how these injuries could impact brain health as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10709201 on NIH RePORTER |
What this research studies
This research aims to explore how traumatic brain injury (TBI) and repetitive head impacts may influence the risk of developing Alzheimer's disease and related dementias. By analyzing data from five major NIH-funded aging studies, the project will utilize both existing and newly collected information from over 19,700 individuals. The goal is to clarify the relationship between head trauma and dementia, addressing previous inconsistencies in findings through advanced statistical methods. This comprehensive approach will help identify risk factors and improve understanding of dementia progression in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who have experienced traumatic brain injuries or repetitive head impacts.
Not a fit: Patients who have not experienced any form of head trauma or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies and interventions for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown mixed results regarding the link between head trauma and dementia, making this approach both novel and necessary for clearer insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dams-O'connor, Kristen — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dams-O'connor, Kristen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.