Investigating the link between traumatic brain injury and Alzheimer's disease risk
Leveraging Existing Aging Research Networks to investigate TBI and AD/ADRD risk (LEARN TBI & AD)
This study is looking at how head injuries and repeated hits to the head might increase the chances of developing Alzheimer's and other types of dementia, using information from over 19,700 people to help understand this important connection for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10533343 on NIH RePORTER |
What this research studies
This research aims to explore how traumatic brain injuries (TBI) and repetitive head impacts (RHI) may influence the risk of developing Alzheimer's disease (AD) and related dementias (ADRD). By analyzing data from over 19,700 individuals across five major studies on aging, the project seeks to clarify the relationship between head trauma and dementia. The research will utilize advanced statistical methods to harmonize data and conduct thorough analyses, providing insights into how these injuries may affect cognitive health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults aged 21 and above who have experienced traumatic brain injuries or repetitive head impacts.
Not a fit: Patients who have not experienced any form of head trauma or who are younger than 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease and related dementias in individuals with a history of head injuries.
How similar studies have performed: Previous research has shown mixed results regarding the link between head trauma and dementia, indicating that this approach could provide novel insights into an important area of study.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Dams-O'connor, Kristen — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dams-O'connor, Kristen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.