Investigating the link between small brain bleeds and walking problems in older adults
Cerebral microhemorrhages and gait abnormalities in aging
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10826074
This study is looking at how tiny brain bleeds might affect thinking and movement in older adults, especially those with high blood pressure, and it hopes to find ways to prevent these issues by learning more about how these bleeds happen.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10826074 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how cerebral microhemorrhages, or small brain bleeds, contribute to cognitive and mobility issues in aging individuals. By examining the mechanisms that lead to these microbleeds, particularly in relation to aging and hypertension, the study aims to identify potential prevention strategies. The research will utilize innovative preclinical models to explore the role of senescent endothelial cells in the brain's microcirculation. Patients may be involved in providing data or samples to help elucidate these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive impairment or gait abnormalities, particularly those with a history of hypertension.
Not a fit: Patients who are younger or do not have any cognitive or mobility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for cognitive decline and mobility issues in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the mechanisms of cerebral microhemorrhages, suggesting that this approach could yield valuable insights.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: UNGVARI, ZOLTAN ISTVAN — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: UNGVARI, ZOLTAN ISTVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease