Investigating the link between small brain bleeds and walking problems in older adults
Official title: Cerebral microhemorrhages and gait abnormalities in aging
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10826074 · Data updated 2026-11-12
This study is looking at how tiny brain bleeds might affect thinking and movement in older adults, especially those with high blood pressure, and it hopes to find ways to prevent these issues by learning more about how these bleeds happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $433,015 |
| NIH project number | 2R01AG055395-06A1 |
| Project ID | NIH-10826074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults experiencing cognitive impairment or gait abnormalities, particularly those with a history of hypertension.
✕Less likely to help
Patients who are younger or do not have any cognitive or mobility issues may not benefit from this research.
What this research studies
This research focuses on understanding how cerebral microhemorrhages, or small brain bleeds, contribute to cognitive and mobility issues in aging individuals. By examining the mechanisms that lead to these microbleeds, particularly in relation to aging and hypertension, the study aims to identify potential prevention strategies. The research will utilize innovative preclinical models to explore the role of senescent endothelial cells in the brain's microcirculation. Patients may be involved in providing data or samples to help elucidate these connections.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies for cognitive decline and mobility issues in older adults.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of cerebral microhemorrhages, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Ungvari, Zoltan Istvan — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Ungvari, Zoltan Istvan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.