Investigating the link between sleep quality and Alzheimer's disease in older Mexican Americans and Non-Hispanic Whites
Official title: Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic Whites
Funded at University of California, San Francisco · NIH-10653856 · Data updated 2026-11-12
This study is looking at how the quality of sleep might influence the chances of older Mexican Americans and Non-Hispanic Whites developing Alzheimer's and similar conditions, hoping to find ways to improve sleep and help protect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 15, 2019 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $764,815 |
| NIH project number | 5R01AG066137-05 |
| Project ID | NIH-10653856 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly Mexican Americans and Non-Hispanic Whites, who may be experiencing cognitive impairment or sleep disorders.
✕Less likely to help
Patients who are younger than 50 or do not have concerns related to sleep quality or cognitive impairment may not benefit from this research.
What this research studies
This research explores how sleep quality affects the risk of developing Alzheimer's Disease and related disorders among older Mexican Americans and Non-Hispanic Whites. It aims to identify both subjective and objective measures of sleep quality and their association with cognitive impairment. By leveraging an existing study on aging in Latino elders, the research will involve 1,000 participants to uncover the mechanisms linking sleep issues to cognitive decline. The findings could lead to targeted interventions for improving sleep and potentially reducing the risk of Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Alzheimer's disease through better sleep management.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between sleep quality and cognitive decline, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yaffe, Kristine — University of California, San Francisco
- Study coordinator: Yaffe, Kristine
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.