Investigating the link between sleep apnea and brain changes in older adults
Establishing Sleep Apnea as a non-cognitive phenotype of brainstem ADRD pathologies in older adults
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10809683
This study is looking at how Alzheimer’s disease and similar conditions might impact sleep apnea in older adults, aiming to understand how changes in the brain could affect breathing during sleep, which could help improve care for those with these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10809683 on ClinicalTrials.gov |
What this research studies
This research explores how Alzheimer’s disease and related dementias (ADRD) may affect sleep apnea in older adults. It aims to understand the relationship between ADRD pathologies and the brain circuits that control breathing during sleep. By using novel sensors and studying brain tissues, the research seeks to identify specific changes that could lead to sleep apnea. The findings could help in recognizing sleep apnea as a significant aspect of ADRD in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who may be experiencing symptoms of sleep apnea or have been diagnosed with Alzheimer’s disease or related dementias.
Not a fit: Patients under the age of 65 or those without any signs of sleep apnea or ADRD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for sleep apnea in older adults with dementia.
How similar studies have performed: While the connection between sleep apnea and ADRD is being explored, this specific approach of examining brainstem circuits in humans is relatively novel and has not been extensively tested.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VANDERHORST, VERONIQUE — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: VANDERHORST, VERONIQUE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.