Investigating the link between sepsis and delirium through protein analysis
Exploring the sepsis-delirium connection through glycoproteomics
This study is looking at how changes in certain proteins in the blood might be linked to sepsis and delirium in seriously ill patients, with the hope of finding new ways to understand and track these conditions better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10677027 on NIH RePORTER |
What this research studies
This research focuses on understanding how changes in protein glycosylation are related to sepsis and delirium. By developing advanced algorithms and mass spectrometry techniques, the team aims to identify specific glycoprotein alterations in the blood of critically ill patients. These findings could help in discovering biomarkers that correlate with different clinical symptoms and long-term cognitive effects associated with sepsis. The research will utilize data from existing patient programs to enhance the understanding of these complex conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include critically ill patients diagnosed with sepsis who are being monitored for cognitive outcomes.
Not a fit: Patients with non-sepsis related critical illnesses or those not experiencing cognitive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients suffering from sepsis and its associated cognitive dysfunction.
How similar studies have performed: Previous research has shown promise in using glycoproteomics to identify biomarkers in various diseases, suggesting potential success for this novel approach.
Where this research is happening
Chicago, UNITED STATES
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Patrie, Steven Matthew — Northwestern University
- Study coordinator: Patrie, Steven Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.