Investigating the link between oral bacteria and HPV in HIV-positive adults
Official title: Cross Sectional Association of the Oral Microbiota and the Inflammasome with Oral HPV among HIV+ Adults
Funded at Comprehensive Cancer Center/ Univ/pr · NIH-10447167 · Data updated 2026-11-12
This study is looking at how the germs in your mouth and certain proteins in your immune system might affect the lasting presence of HPV infections in adults with HIV, with the goal of finding ways to catch HPV-related cancers early and improve treatment options for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Comprehensive Cancer Center/ Univ/pr NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project start | July 7, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $149,884 |
| NIH project number | 5R21CA264606-02 |
| Project ID | NIH-10447167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are living with HIV and may be at risk for HPV-related complications.
✕Less likely to help
Patients who are not living with HIV or who do not have oral HPV infections may not benefit from this research.
What this research studies
This research explores how the oral microbiota and inflammasome proteins may influence the persistence of oral HPV infections in adults living with HIV. By examining the relationship between these factors and HPV, the study aims to identify potential biomarkers for early detection of HPV-related cancers. The approach involves analyzing oral samples from participants to assess the microbiome and immune responses. This could lead to improved strategies for cancer prevention and personalized treatment for those affected.
Why it matters
Potential benefit: If successful, this research could lead to better early detection methods and treatment options for HPV-related cancers in HIV-positive individuals.
How similar studies have gone: While the specific combination of oral microbiota and inflammasome investigation in this context is novel, related studies have shown promising results in understanding HPV and immune interactions.
Where this research is happening
-
Comprehensive Cancer Center/ Univ/pr
San Juan, United States Active
Researchers
- Principal investigator: Perez-Santiago, Josue — Comprehensive Cancer Center/ Univ/pr
- Study coordinator: Perez-Santiago, Josue
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.