Investigating the link between NPTX2 and tau in Alzheimer's disease
Official title: Linking NPTX2 and Tau pathophysiology in AD
Funded at Johns Hopkins University · NIH-11075799 · Data updated 2026-11-12
This study is looking at how a protein called NPTX2 interacts with another protein linked to Alzheimer's disease, to help us understand how brain activity affects memory and thinking in people with the condition, which could lead to new ways to treat it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $122,813 |
| NIH project number | 5R21AG085577-02 |
| Project ID | NIH-11075799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or mild cognitive impairment.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research explores how NPTX2, a protein involved in neuronal signaling, interacts with tau pathology in Alzheimer's disease (AD). By examining the relationship between NPTX2 levels in cerebrospinal fluid and tau protein, the study aims to understand how neuronal activity influences tau spread and its impact on cognitive function. The researchers will utilize advanced imaging techniques to observe these interactions in a model of Alzheimer's, providing insights into potential mechanisms of disease progression. Patients may benefit from a better understanding of how these proteins affect their condition and could lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between NPTX2 and tau pathology, indicating a potential for significant advancements in Alzheimer's research.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Worley, Paul F — Johns Hopkins University
- Study coordinator: Worley, Paul F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.