Investigating the link between non-alcoholic fatty liver disease and kidney stone risk
Non-alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis
This study is looking at how having non-alcoholic fatty liver disease might raise the chances of getting kidney stones, and it’s for people with this liver condition who can help by sharing some samples for research.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11042802 on NIH RePORTER |
What this research studies
This research explores how non-alcoholic fatty liver disease (NAFLD) may increase the risk of developing kidney stones through the synthesis of oxalate in the body. It focuses on understanding the metabolic processes involved, particularly how ascorbic acid and glyoxylate contribute to oxalate production. By examining liver biopsies and urine samples from affected individuals, the study aims to identify potential biomarkers and mechanisms that link NAFLD with kidney stone formation. Patients may be asked to provide samples and participate in assessments to help clarify these relationships.
Who could benefit from this research
Good fit: Ideal candidates include individuals aged 21 and older who have been diagnosed with non-alcoholic fatty liver disease and may also be at risk for kidney stones.
Not a fit: Patients without non-alcoholic fatty liver disease or those who do not have a history of kidney stones may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention strategies for kidney stones in patients with non-alcoholic fatty liver disease.
How similar studies have performed: Previous studies have indicated a connection between metabolic disorders and kidney stone risk, suggesting that this research could build on established findings.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Wood, Kyle D — University of Alabama at Birmingham
- Study coordinator: Wood, Kyle D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.