Investigating the link between neurovascular calcification and Alzheimer's disease in South American populations
Official title: Neurovascular calcification, Alzheimer’s disease and related dementias in two Native South American populations
Funded at University of Southern California · NIH-10662151 · Data updated 2026-11-12
This study is looking at how calcium buildup in certain blood vessels might affect brain health and memory, especially for people with Alzheimer's disease, by examining two Native South American groups to find out how it impacts their brain size and thinking skills.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,452,559 |
| NIH project number | 1RF1AG082201-01 |
| Project ID | NIH-10662151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from the Tsimane and Moseten populations, particularly those experiencing mild cognitive impairment or at risk for Alzheimer's disease.
✕Less likely to help
Patients outside of the Tsimane and Moseten populations or those without cognitive impairment may not benefit from this research.
What this research studies
This research explores how neurovascular calcification affects brain health, particularly in relation to Alzheimer's disease and related dementias. By studying two Native South American populations, the Tsimane and Moseten, researchers aim to understand the impact of calcification in the internal carotid arteries on brain volume and cognitive function. The study will utilize advanced imaging techniques to analyze the structure and characteristics of these blood vessels, providing insights into the mechanisms behind cognitive decline. This research could lead to better understanding and potential interventions for Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of Alzheimer's disease and lead to improved prevention or treatment strategies for patients.
How similar studies have gone: While research on neurovascular calcification and Alzheimer's disease is ongoing, this specific approach focusing on indigenous populations is relatively novel and untested.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Irimia, Andrei — University of Southern California
- Study coordinator: Irimia, Andrei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.