Investigating the link between mitochondrial DNA haplogroup J and Alzheimer's disease
Mechanistic Basis of the mtDNA Haplogroup J-Alzheimer's Disease Association
This study is looking at how certain genetic changes in mitochondrial DNA might affect the risk and progression of Alzheimer's disease, and it's for anyone interested in understanding how our genes and aging can influence brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10565875 on NIH RePORTER |
What this research studies
This research explores how specific genetic variations in mitochondrial DNA, particularly haplogroup J, may influence the risk and progression of Alzheimer's disease (AD). By using a combination of laboratory techniques and clinical data, the researchers aim to understand the functional impact of these genetic variants on mitochondrial health and their relationship with aging. The study involves creating specialized cell lines to test mitochondrial function and analyzing patient samples to uncover potential biomarkers associated with AD. This comprehensive approach seeks to provide insights into the biological mechanisms underlying Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 80 and over who are diagnosed with Alzheimer's disease or exhibit symptoms of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and potential therapeutic targets for Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Previous research has indicated a connection between mitochondrial function and Alzheimer's disease, suggesting that this approach has the potential for significant findings.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Swerdlow, Russell H. — University of Kansas Medical Center
- Study coordinator: Swerdlow, Russell H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.