Investigating the link between maternal asthma and preeclampsia to understand childhood asthma risk
Integrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood Asthma
This study is looking at how a mother's asthma and a condition called preeclampsia during pregnancy might be linked and could affect the chances of their child developing asthma later on, using genetic information from both moms and their babies to find clues that could help prevent asthma in kids.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10756475 on NIH RePORTER |
What this research studies
This research aims to explore how maternal asthma and preeclampsia are interconnected and how they may contribute to the risk of childhood asthma. By analyzing genomic data from mothers during pregnancy and their newborns, the study seeks to identify specific genes and biological pathways that could indicate a higher risk for asthma in children. The approach involves advanced genomic techniques, including Next-Generation Sequencing, to gather and analyze data from maternal blood samples taken at different stages of pregnancy. The findings could lead to better diagnostic tools and preventive strategies for childhood asthma.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women with a history of asthma or preeclampsia.
Not a fit: Patients who are not pregnant or do not have a history of asthma or preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early identification and prevention strategies for childhood asthma, improving health outcomes for affected children.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to asthma, suggesting that this integrative approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mirzakhani, Hooman — Brigham and Women's Hospital
- Study coordinator: Mirzakhani, Hooman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.