Investigating the link between late-onset epilepsy and cognitive decline in older adults

Late-onset Epilepsy and Cognition

NIH-funded research Johns Hopkins University · NIH-10831100

This study is looking at how late-onset epilepsy in people aged 60 and older might be linked to memory and thinking problems, like those seen in Alzheimer's disease, to see if it could help us find ways to spot and address these issues early on.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-10831100 on NIH RePORTER

What this research studies

This research explores how late-onset epilepsy, which occurs in individuals aged 60 and older without a known cause, may be connected to cognitive decline and conditions like Alzheimer's disease. By analyzing data from an ongoing study and recruiting new participants, the research aims to determine if late-onset epilepsy is a marker for future cognitive impairment. The study will assess cognitive performance and biomarkers in patients with and without late-onset epilepsy to identify potential early intervention strategies.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 60 and above who have experienced late-onset epilepsy.

Not a fit: Patients under the age of 60 or those with epilepsy due to known causes, such as stroke, may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to earlier interventions for cognitive decline in older adults with late-onset epilepsy.

How similar studies have performed: Previous research has indicated a potential link between epilepsy and cognitive decline, suggesting that this approach may yield valuable insights.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.