Investigating the link between iron levels and symptoms in psychotic disorders
Official title: Iron deficits and their relationship with symptoms and cognition in Psychotic Spectrum Disorders
Funded at New York University School of Medicine · NIH-11010817 · Data updated 2026-11-12
This study is looking at how low iron levels might influence symptoms and thinking skills in people with psychotic spectrum disorders, and it involves using brain scans to see how iron in the brain relates to these issues in both teens and adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $609,521 |
| NIH project number | 5R01MH129934-03 |
| Project ID | NIH-11010817 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with psychotic spectrum disorders, particularly those experiencing cognitive challenges.
✕Less likely to help
Patients with psychotic disorders who do not have any iron metabolism issues or those who are not experiencing cognitive deficits may not benefit from this research.
What this research studies
This research explores how iron deficits may affect symptoms and cognitive abilities in individuals with psychotic spectrum disorders (PSD). By using advanced MRI techniques, the study aims to measure iron content in specific brain regions and determine its relationship with the severity of symptoms and cognitive function. The research focuses on various age groups, from adolescents to adults, to understand how iron metabolism impacts brain health and disorder progression. Participants may undergo brain imaging to assess iron levels and their potential effects on mental health.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that address cognitive deficits in patients with psychotic disorders by targeting iron metabolism.
How similar studies have gone: While the relationship between iron levels and cognitive function in psychotic disorders is an emerging area, previous studies have suggested potential links, indicating that this research could build on existing findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Lazar, Mariana — New York University School of Medicine
- Study coordinator: Lazar, Mariana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.