Investigating the link between inflammation and atrial fibrillation related to alcohol use.
The JNK2-NLRP3 nexus in atrial fibrillation and its anti-AF therapeutic potentials
This study is looking at how drinking too much alcohol can make heart rhythm problems, like atrial fibrillation, worse in older adults, and it hopes to find new ways to help treat this condition by understanding how alcohol causes inflammation in the heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11094898 on NIH RePORTER |
What this research studies
This research focuses on understanding how excessive alcohol intake contributes to atrial fibrillation (AF), a common heart rhythm disorder, particularly in older adults. It aims to explore the mechanisms by which inflammation, triggered by alcohol consumption, exacerbates AF risk. By studying the interactions between specific inflammatory pathways and stress kinases, the research seeks to identify new therapeutic targets that could improve treatment outcomes for patients suffering from AF. The approach includes analyzing human heart tissue to observe the effects of alcohol on inflammation and heart function.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who have experienced atrial fibrillation and have a history of excessive alcohol consumption.
Not a fit: Patients who do not consume alcohol and have no history of atrial fibrillation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for atrial fibrillation, particularly for patients with a history of alcohol use.
How similar studies have performed: Previous research has shown that targeting inflammation can be beneficial in other cardiovascular conditions, suggesting potential for success in this novel approach.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Ai, Xun — Ohio State University
- Study coordinator: Ai, Xun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.