Investigating the link between immune response and depression
Complement Component, Neuroinflammation and Depression
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-10670822
This study is looking at how a part of the immune system called C3 affects depression, especially when someone is dealing with long-term stress, to find new ways to help people feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10670822 on ClinicalTrials.gov |
What this research studies
This research explores how the immune system, particularly the complement component C3, influences depression, especially in the context of chronic stress. It aims to understand the role of neuroinflammation in depressive behaviors by examining the activation of specific immune pathways in the brain. By studying the effects of C3 on microglia, the brain's immune cells, the research seeks to identify potential new treatments that could improve outcomes for patients suffering from depression. The approach includes both animal models and human tissue analysis to establish a clearer connection between inflammation and mood disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing depression, particularly those with a history of chronic stress.
Not a fit: Patients with depression not linked to immune system dysfunction or chronic stress may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for depression by targeting specific immune mechanisms.
How similar studies have performed: Previous studies have shown promise in using anti-inflammatory agents for treating depression, suggesting that targeting specific immune pathways could be a viable approach.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PILLAI, ANILKUMAR — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: PILLAI, ANILKUMAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.