Investigating the link between hypertension and Alzheimer's risk in US veterans
Official title: Hypertension, Blood Pressure Targets, and Alzheimer’s Disease and Dementia Risk and Disparities among Nationally Representative US Veterans
Funded at University of California, San Francisco · NIH-10806472 · Data updated 2026-11-12
This study is looking at how managing high blood pressure might affect the chances of U.S. veterans developing Alzheimer's and other types of dementia, especially for those who might be at greater risk due to their background or military experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $836,669 |
| NIH project number | 1R01AG085481-01 |
| Project ID | NIH-10806472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are U.S. veterans aged 65 and older, particularly those with a history of hypertension or other cardiovascular risk factors.
✕Less likely to help
Patients who are not veterans or those under 65 years of age may not benefit from this research.
What this research studies
This research focuses on understanding how hypertension and its treatment may influence the risk of Alzheimer's Disease and Related Dementias (ADRD) among U.S. veterans. By utilizing a large dataset from the Veterans Health Administration, the study aims to explore the relationship between blood pressure management and dementia risk, particularly in diverse subgroups of veterans who may be at higher risk due to factors like race, ethnicity, and military-related exposures. The research will analyze electronic health records to identify patterns and disparities in health outcomes, providing valuable insights into effective prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved hypertension management strategies that reduce the risk of Alzheimer's and related dementias in veterans.
How similar studies have gone: Previous research has indicated that managing hypertension can positively impact cognitive health, suggesting that this approach may yield significant findings.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Yaffe, Kristine — University of California, San Francisco
- Study coordinator: Yaffe, Kristine
Related research
Other NIH-funded projects on the same topics.
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Hypertension, Blood Pressure Targets, and Alzheimer’s Risk and Disparities in US Veterans
This project looks at how blood pressure control and its targets relate to Alzheimer's and related dementia risk in diverse U.S. veterans.
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Understanding High Blood Pressure, Treatment Goals, and Dementia Risk in US Veterans
This project looks at how high blood pressure and its treatment might affect the risk of Alzheimer's disease and related dementias in US veterans.
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Global picture of dementia risk and memory loss across the world
A large international effort gathers data from many studies to understand how dementia and memory problems develop around the world, using shared information to reveal patterns and risk factors.
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Automated language analysis for Alzheimer’s and frontotemporal dementia across Latino and English-speaking groups
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Automated language analysis to help diagnose Alzheimer’s and frontotemporal dementia in Latino and English speakers
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.