Investigating the link between hidden brain changes and confusion after surgery in older adults
Preoperative Occult Neurodegeneration and Postoperative Delirium
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11020958
This study is looking at how changes in the brain might cause confusion after surgery in older adults, and it aims to help improve recovery for these patients by checking their brain health before and after their operations.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11020958 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how hidden neurodegenerative changes in the brain may contribute to confusion, known as delirium, that often occurs after surgery in older adults. The study will involve evaluating older surgical patients before their procedures for any cognitive impairments and then monitoring them after surgery for signs of delirium and longer-term cognitive decline. Researchers will use advanced blood tests and brain imaging techniques to identify neurodegeneration and neural injury. By uncovering these connections, the research aims to improve outcomes for older patients undergoing surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 65 and above who are scheduled for non-cardiac surgical procedures.
Not a fit: Patients under the age of 65 or those not undergoing surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for delirium in older surgical patients, potentially reducing the risk of long-term cognitive decline.
How similar studies have performed: Previous research has indicated that understanding the relationship between neurodegeneration and postoperative outcomes can lead to significant advancements in patient care, suggesting that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CROSBY, GREGORY — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: CROSBY, GREGORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.