Investigating the link between gut metabolites, immune cells, and high blood pressure
Official title: Gut Metabolites, T cells, and Salt-Sensitive Hypertension
Funded at Augusta University · NIH-11004129 · Data updated 2026-11-12
This study is looking at how certain proteins in our diet and substances made by gut bacteria can affect the immune system and lead to high blood pressure in people who are sensitive to salt, with the hope of finding ways to help manage blood pressure through diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $566,873 |
| NIH project number | 5R01HL166458-03 |
| Project ID | NIH-11004129 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with salt-sensitive hypertension, particularly those who experience elevated blood pressure in response to high salt intake.
✕Less likely to help
Patients with salt-resistant hypertension or those who do not have hypertension may not benefit from this research.
What this research studies
This research explores how certain dietary proteins and gut metabolites influence the immune response and contribute to salt-sensitive hypertension. By studying a specific animal model, the researchers aim to understand the mechanisms by which immune cells, particularly CD4+ T cells, affect kidney function and blood pressure regulation. The study will involve examining the role of free radicals produced by these immune cells in the development of hypertension, especially in individuals who are sensitive to salt intake. The findings could provide insights into dietary interventions that may help manage blood pressure.
Why it matters
Potential benefit: If successful, this research could lead to new dietary recommendations or treatments for individuals with salt-sensitive hypertension, potentially reducing their risk of cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between diet, immune response, and hypertension, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Mattson, David L. — Augusta University
- Study coordinator: Mattson, David L.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.