Investigating the link between gut health and cognitive decline in Alzheimer's disease.
Gut Immunity, Neurovascular Dysregulation and Cognitive Impairment
This study is looking at how certain immune cells from the gut might affect brain health and thinking skills in people with Alzheimer's and similar conditions, with the hope of finding new ways to help improve memory and cognitive function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10900717 on NIH RePORTER |
What this research studies
This research explores how the immune system, particularly cells from the gut, may influence brain health and cognitive function in individuals with Alzheimer's disease and related dementias. It focuses on the role of specific immune cells, known as Th17 cells, and their interaction with brain blood vessels and inflammation. By understanding these connections, the research aims to uncover new pathways that could lead to potential treatments for cognitive impairment associated with Alzheimer's disease. Patients may be involved in studies that assess their gut health and immune responses.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing cognitive decline.
Not a fit: Patients with non-neurodegenerative cognitive impairments or those without Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of gut health in cognitive function, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Faraco, Giuseppe — Weill Medical Coll of Cornell Univ
- Study coordinator: Faraco, Giuseppe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.