Investigating the link between G6PD deficiency and heart disease
G6PD Deficiency and Atherosclerosis
This study is looking at how a common genetic condition called G6PD deficiency might affect heart health by exploring how certain immune cells help protect against heart disease, which could lead to new treatments for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11028236 on NIH RePORTER |
What this research studies
This research explores how glucose-6-phosphate dehydrogenase deficiency (G6PD-d), a common genetic condition affecting many individuals worldwide, may contribute to the development of atherosclerosis, a type of heart disease. The study utilizes a novel mouse model that mimics human G6PD-d to examine the role of specific immune cells, particularly B-1b cells, in protecting against atherosclerosis. By analyzing how G6PD-d affects these immune cells and their production of protective antibodies, the research aims to uncover potential mechanisms that could lead to new treatments for cardiovascular disease. Patients may benefit from insights gained regarding their G6PD-d status and its implications for heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glucose-6-phosphate dehydrogenase deficiency.
Not a fit: Patients without G6PD deficiency or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cardiovascular disease in patients with G6PD deficiency.
How similar studies have performed: Previous research has indicated a potential link between G6PD deficiency and cardiovascular disease, but this specific approach using a humanized mouse model is novel.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Mcnamara, Coleen a — University of Virginia
- Study coordinator: Mcnamara, Coleen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.