Investigating the link between G6PD deficiency and heart disease

Who could benefit from this research

What this research studies

This research explores how glucose-6-phosphate dehydrogenase deficiency (G6PD-d), a common genetic condition affecting many individuals worldwide, may contribute to the development of atherosclerosis, a type of heart disease. The study utilizes a novel mouse model that mimics human G6PD-d to examine the role of specific immune cells, particularly B-1b cells, in protecting against atherosclerosis. By analyzing how G6PD-d affects these immune cells and their production of protective antibodies, the research aims to uncover potential mechanisms that could lead to new treatments for cardiovascular disease. Patients may benefit from insights gained regarding their G6PD-d status and its implications for heart health.

Why it matters

Where this research is happening

• University of Virginia
  Charlottesville, United States Active

Researchers

• Principal investigator: Mcnamara, Coleen a — University of Virginia
• Study coordinator: Mcnamara, Coleen a

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.