Investigating the link between fungal translocation and lung health in people with HIV
Relationship of fungal translocation, inflammation, and pulmonary function in HIV
This study is looking at how a substance from fungi affects inflammation and breathing in people with HIV, hoping to learn more about lung health and improve care for those with COPD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11116998 on NIH RePORTER |
What this research studies
This research explores how fungal translocation, which is the movement of fungi or their products into the bloodstream, affects inflammation and lung function in individuals living with HIV. The study focuses on a specific fungal component called 1,3-beta-D-glucan (BDG), which is believed to trigger inflammation and may worsen respiratory symptoms. By examining the relationship between BDG levels and lung health, the research aims to uncover new insights into the mechanisms behind chronic obstructive pulmonary disease (COPD) in HIV patients. Participants may undergo tests to measure BDG levels and assess lung function, contributing to a better understanding of their health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing respiratory symptoms or have been diagnosed with chronic obstructive pulmonary disease (COPD).
Not a fit: Patients who do not have HIV or those without respiratory issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for lung health in individuals with HIV.
How similar studies have performed: Previous research has indicated a connection between microbial translocation and inflammation in HIV, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Methe, Barbara — University of Pittsburgh at Pittsburgh
- Study coordinator: Methe, Barbara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.