Investigating the link between folate intake and colorectal cancer
Multidisciplinary Study of Folate Intake and Colorectal Cancer
This study is looking at how the amount of folate you get from your diet might affect the risk and progression of colorectal cancer, and it's designed for people who have been diagnosed with this type of cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11064284 on NIH RePORTER |
What this research studies
This research explores how different levels of folate intake may influence the development and progression of colorectal cancer (CRC). By analyzing data from over 1,100 CRC patients and integrating advanced genetic sequencing techniques, the study aims to clarify the relationship between dietary folate sources and cancer outcomes. The researchers will examine both short- and long-term folate consumption and its potential mechanisms in cancer development. This comprehensive approach seeks to fill existing knowledge gaps regarding folate's role in CRC risk and survival.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of colorectal cancer or those at high risk for developing the disease.
Not a fit: Patients who do not consume dietary folate or have no risk factors for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations for colorectal cancer prevention and management.
How similar studies have performed: While there have been studies on folate and cancer, this research is novel in its integration of whole-exome sequencing with population-based cohort data.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Zhang, Xuehong — Yale University
- Study coordinator: Zhang, Xuehong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.