Investigating the link between environmental factors and heart disease risk in patients with substance use disorder.
Official title: Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY)
Funded at Louisiana State Univ Hsc Shreveport · NIH-11194080 · Data updated 2026-11-12
This study is looking at how certain chemicals in the blood might affect heart disease risk in people with substance use disorder, and it aims to gather information that could help improve treatments for these individuals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | September 17, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $219,000 |
| NIH project number | 5P20GM121307-07 |
| Project ID | NIH-11194080 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with substance use disorder who may also be at risk for cardiovascular disease.
✕Less likely to help
Patients without substance use disorder or those not at risk for cardiovascular disease may not benefit from this research.
What this research studies
This research explores how certain chemicals in the blood, known as volatile organic compounds (VOCs), relate to heart disease risk in individuals with substance use disorder (SUD). By analyzing data from over 101,000 participants, the study will measure oxidative balance scores (OBS) and VOC levels to understand their connection to cardiovascular disease (CVD). The research will involve collecting plasma samples from 800 patients to identify those with SUD and assess their oxidative stress and heart disease risk. The goal is to create a centralized database that can help in understanding these relationships and potentially guide future treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted interventions for cardiovascular disease in patients with substance use disorder.
How similar studies have gone: Previous research has shown promising results in linking environmental factors and biomarkers to cardiovascular risks, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Bhuiyan, Mohammad Alfrad Nobel — Louisiana State Univ Hsc Shreveport
- Study coordinator: Bhuiyan, Mohammad Alfrad Nobel
Related research
Other NIH-funded projects on the same topics.
-
Newborn screening: using gene and metabolite data to refine true vs false positives
A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.
-
IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Metabolomics clues to how ultra-processed foods affect risk of type 2 diabetes
A scientist-led study will look at how eating different ultra-processed foods may change diabetes risk by using a controlled feeding trial and big population data, focusing on adults.
-
Longitudinal metabolomics in infants with food allergies
A study in infants aims to understand how gut metabolites relate to the development of food allergies, including IgE-mediated and non-IgE cases.
-
Biospecimen, Metabolomics, and Pathology Core for Endometrial Cancer Research
A national, multi-institutional resource collects and analyzes tissue, blood, and metabolites from endometrial cancer patients to support multiple research projects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.